YOU ARE NOW CONNECTED TO THE TOXLINE (1981 FORWARD, NON-ROYALTY) FILE. ==ULCER, DECUBITUS - TOPICAL== 4 AUTHOR Tytgat H AUTHOR Van Asch H TITLE Topical ketanserin in the treatment of decubitus ulcers: double blind study with 2% ketanserin ointment against placebo SOURCE Adv. Ther.; VOL 5 ISS Jul-Aug 1988, P143-152, (REF 39) ABSTRACT IPA COPYRIGHT: ASHP A double blind study was conducted to investigate the effects of topically applied ketanserin (I) compared to placebo on the healing process of decubitus ulcers in 16 multiple sclerosis patients who received either 2% I ointment or placebo twice daily for 3 wk along with supportive wound healing procedures. The parameters measured were ulcer area, granulation, epithelialization, periulcerative inflammation or erythema, and transudate. Clinical signs and symptoms were scored according to a 4 point scale (absent, traces, present, pronounced). Six patients receiving I (75%) and 2 receiving placebo (25%) responded well to treatment within a 3 wk period. Formation of granulation tissue was clearly enhanced under I therapy. The results suggested that topically applied I may be of benefit in the management of decubitus ulcers and for chronic wound care in general. 5 AUTHOR Seiler WO AUTHOR Stahelin HB TITLE Decubitus ulcers: treatment through five therapeutic principles. SOURCE Geriatrics; VOL 40, ISS 9, 1985, P30-44 ABSTRACT Without relief of localized pressure, no healing is possible, and all other therapeutic measures are futile. If other factors are mistakenly blamed (incontinence, perspiration, malnutrition) attention may be diverted from the essential--relief of localized pressure and maintenance of patient mobility. Dressings should protect healing ulcers from mechanical damage and external bacterial recontamination after removal of pathogens by local disinfection. Dressings should be kept moist with Ringer's solution to create conditions that promote new granulation. 7 AUTHOR Moberg S AUTHOR Hoffman L AUTHOR Grennert ML AUTHOR Holst A TITLE A randomized trial of cadexomer iodine in decubitus ulcers. SOURCE J Am Geriatr Soc; VOL 31, ISS 8, 1983, P462-5 ABSTRACT Thirty-four patients with decubitus ulcers were studied in a randomized trial to compare topical cadexomer iodine with the standard decubitus ulcer treatments used in the participating hospitals. There was a significant reduction of ulcer area with both treatments within three weeks; however, eight of 16 patients treated with cadexomer iodine had a reduction of ulcer area of more than 50 per cent, compared with one of 18 patients treated with the standard treatment (P less than 0.01). Twenty-seven patients continued the same treatment for five more weeks, during which time six in the cadexomer iodine group healed, compared with one in the standard treatment group (P less than 0.05). Cadexomer iodine was superior to the standard treatment in removing pus and debris from the ulcer surface and in reducing pain at the ulcer site. It was found to be easy both to apply and to remove from the ulcers and did not stain skin or clothing. Transient smarting during the first hour after application was reported by three patients, and one patient complained of skin irritation. The results show that cadexomer iodine applied daily has a debriding effect on decubitus ulcers and accelerates healing. 3 AUTHOR Burnakis TG AUTHOR Mioduch HJ TITLE Topical metronidazole for decubitus ulcer SOURCE Hosp. Pharm.; VOL 24 ISS Nov 1989, P961-962, (REF 4) ABSTRACT IPA COPYRIGHT: ASHP The use of a topical solution of one percent metronidazole for the treatment of 15 to 20 patients with extensive decubitus ulcers, accompanied by a foul odor, is described. The effects of the therapy were quite pronounced. Within the first 24-48 h the odor disappeared completely and progression of the ulcer was limited. YOU ARE NOW CONNECTED TO THE TOXLINE65 (1965 - 80, NON-ROYALTY) FILE. 1 AUTHOR Lee BY AUTHOR Trainor FS AUTHOR Thoden WR TITLE Topical application of povidone-iodine in the management of decubitus and stasis ulcers SOURCE J. Am. Geriatr. Soc.; VOL 27 ISS Jul 1979, P302-306, (REF 10) ABSTRACT IPA COPYRIGHT: ASHP The efficacy of topical applications of povidone-iodine (Betadine; I) solutions and ointments for the control of infection associated with decubitus and stasis ulcers was evaluated in 18 male outpatients aged 33-68 yr. Dressings were changed twice daily over a period of 42 days. Statistically significant improvement was noted in the following signs and symptoms: edema, pain erythema, ulcer size, and ulcer depth. All patients experienced some degree of symptomatic relief and clinical improvement within 2 weeks after starting therapy. At the end of the study, 67% of the ulcers were clinically cured and 33% showed improvement. Acceptance by the patients was excellent, with no reported side effects or sensitization reactions. I used in a daily regimen of ulcer care can reduce the level of infection and promote healing. 4 AUTHOR Michocki RJ AUTHOR Lamy PP TITLE The care of decubitus ulcers pressure sores. SOURCE J Am Geriatr Soc; VOL 24, ISS 5, 1976, P217-24 ABSTRACT Despite a large volume of literature particularly directed toward treatment, pressure sores (including decubitus ulcers) remain a difficult problem, especially in the nursing home environment. The treatment of pressure sores is somewhat controversial and quite diversified. Selection of a successful therapeutic modality must be preceded by correct evaluation, i.e., whether the sore is superficial or deep, open or closed. The treatment of superficial sores is conservative and directed toward cleanliness, relief of pressure, and exposure to air. Surgical debridement may be indicated. Proteolytic enzymes often are employed as adjunctive therapy, although there are some major drawbacks to their use. The plethora of therapeutic agents suggested for the treatment of deep pressure sores probably is related to the difficulties in achieving success. Surgical debridement is indicated, and proteolytic enzymes are widely used. Possible interactions. and factors leading to the inactivation of these enzymes are discussed, as is the use of various solutions, ointments, gold leaf, oxygen, dry heat, and other adjunctive devices. Of paramount importance in the management of pressure sores is the maintenance of cleanliness and dryness. 5 AUTHOR Van Ort SR AUTHOR Gerber RM TITLE Topical application of insulin in the treatment of decubitus ulcers: pilot study SOURCE Nurs. Res.; VOL 25 ISS Jan-Feb 1976, P9-12, (REF 27) ABSTRACT IPA COPYRIGHT: ASHP To test the hypothesis that there will be a significantly greater increase in the rate of healing of decubitus ulcers in subjects who receive topical insulin therapy than in subjects who receive other forms of therapy, a pilot study was conducted, utilizing a 2-group before and after design. Decubitus ulcers of 6 experimental group subjects were treated with a topical application of 8 units of regular insulin twice a day for 5 days; 8 control group subjects received one of a variety of topical therapies other than insulin. Data were collected on all subjects for a 15-day period. Although generalizations cannot be based on the results of 14 subjects, data analysis showed that insulin was a safe and effective agent in the healing of small, uncomplicated decubitus ulcers.