YOU ARE NOW CONNECTED TO THE TOXLINE (1981 FORWARD, NON-ROYALTY) FILE.
 
                   ==GYNOSTEMMA PENTA AND CHOLESTEROL==
 
1
AUTHOR                    La Cour B
AUTHOR                    Molgaard P
AUTHOR                    Yi Z
TITLE                     Traditional Chinese medicine in treatment of
                          hyperlipidemia
SOURCE                    J. Ethnopharmacol.; VOL 46 ISS 2 1995,
                          P125-129, (REF 9)
ABSTRACT                  IPA  COPYRIGHT: ASHP  The antilipemic
                          activity of a decoction of Nelumbo nucifera
                          and Gynostemma pentaphyllum in rats and quail
                          on high lipid diets is described. The
                          decoction exhibited significant antilipemic
                          activity reducing triglycerides and
                          cholesterol following oral administration.
 
1
AUTHOR                    Wang C
AUTHOR                    Wang X
AUTHOR                    Li Y
AUTHOR                    Deng S
AUTHOR                    Jiang Y
AUTHOR                    Yue L
TITLE                     [A preliminary observation of preventive and
                          blocking effect of Gynostemma pentaphyllum
                          (Thunb) Makino on esophageal cancer in rats]
SOURCE                    Hua Hsi I Ko Ta Hsueh Hsueh Pao; VOL 26, ISS
                          4, 1995, P430-2
ABSTRACT                  Gynostemma pentaphyllum (Thunb) Makino is a
                          kind of natural plant growing in the southern
                          provinces of China. In this experiment, rats
                          were given drinks of 2% Gynostemma
                          Pentaphyllum (Thunb) makino aqua boiled
                          solution freely for 2 weeks before
                          administration of carcinogen. Subsequently,
                          the rats were injected with carcinogen (MANA)
                          for 18 weeks and were sacrificed at
                          intervals. The result showed that the number
                          of cases of esophageal epithelial papilloma,
                          the average number of tumor and the incidence
                          of esophageal cancer in the experimental
                          group were lower than those in the control
                          group (MANA only), though no statistical
                          significant difference was found. The
                          initiation of cancer was delayed for 6 weeks.
                          These indicated that Gynostemma Pentaphllum
                          Makino might have some preventive and
                          blocking effect on esophageal cancer in rats.
 
9
AUTHOR                    Lin JM
AUTHOR                    Lin CC
AUTHOR                    Chiu HF
AUTHOR                    Yang JJ
AUTHOR                    Lee SG
TITLE                     Evaluation of the anti-inflammatory and
                          liver-protective effects of anoectochilus
                          formosanus, ganoderma lucidum and gynostemma
                          pentaphyllum in rats.
SOURCE                    Am J Chin Med; VOL 21, ISS 1, 1993, P59-69
ABSTRACT                  The pharmacological effects of Anoectochilus
                          formosanus, Ganoderma lucidum and Gynostemma
                          pentaphyllum were studied against
                          carrageenan-induced paw edema and
                          CC1(4)-induced hepatotoxicity in rats. The
                          water extracts of G. pentaphyllum and G.
                          lucidum were found to possess significant
                          anti-inflammatory activity against
                          carrageenan induced edema. The administration
                          of Gynostemma pentaphyllum displayed an
                          activity even more potent than indomethacin.
                          In contrast, Anoectochilus formosanus showed
                          a delayed onset of anti-inflammatory activity
                          starting from 4 hrs post carrageenan
                          administration. However, A. formosanus
                          significantly decreased the acute increase in
                          serum GOT and GPT level caused by CC1(4).
                          Histological changes such as necrosis, fatty
                          change, ballooning degeneration, inflammatory
                          infiltration of lymphocytes and Kupffer cells
                          around the central vein were simultaneously
                          improved by the treatment of A. formosanus.