YOU ARE NOW CONNECTED TO THE TOXLINE (1981 FORWARD, NON-ROYALTY) FILE. ==PAPILLOMA, INVERTED - NASAL== 1 AUTHOR Deitmer T AUTHOR Wiener C TITLE Is there an occupational etiology of inverted papilloma of the nose and sinuses? SOURCE Acta Otolaryngol (Stockh); VOL 116, ISS 5, 1996, P762-5 ABSTRACT The etiology of inverted papilloma is believed to be of viral origin, as viruses or viral material is found in these tumors of the nose and paranasal sinuses. As the nose is the first defense line of the respiratory tract, we suspected an etiology of airborne pollution as well, especially occupational pollution. We examined a group of 47 patients treated in our department for nasal inverted papilloma, asking about lifelong professional history and occupational exposure. A matched control group of patients with non-malignant diseases was included in the study. We found a significantly higher degree of occupational exposure to different smokes, dusts, and aerosols in the case group. No similar results have been published to our knowledge. To obtain better proof of the role of possible noxious agents, a study technically investigating exposure is mandatory. 2 AUTHOR Cardesa A AUTHOR Traserra J AUTHOR Bombi JA AUTHOR Mohr U TITLE Tumors of the nasal cavities induced in rats by 2,2-dioxopropyl-N-propylnitrosamine. Comparative aspects with man. SOURCE J Cancer Res Clin Oncol; VOL 108, ISS 1, 1984, P114-20 ABSTRACT Weekly SC administration of 2,2-dioxopropylnitrosamine to 88 Sprague-Dawley rats resulted in the induction of 76 separate neoplasms in the respiratory region of the nasal cavities. No tumors of the olfactory region were found. Histologically there were 37 squamous papillomas, 17 transitional papillomas, and 22 squamous cell carcinomas. These tumors were compared with a selected group of 53 related human tumors of the nasal and paranasal cavities, consisting of 11 squamous cell papillomas, 13 transitional papillomas, and 29 squamous cell carcinomas. While the experimental squamous cell papillomas showed a striking histological resemblance with the squamous papillomas observed in man, none of the experimental transitional papillomas had evidence of the characteristics inverted pattern seen in humans; nevertheless, the experimental tumors showed signs of incomplete squamous metaplasia and preservation of intraepithelial secretory glands, features commonly seen in transitional papillomas of man. The squamous cell carcinomas of this experiment were very similar to the corresponding human tumors in morphology and sex incidence. In both species a significant number of squamous cell carcinomas were keratinizing and of a high grade of histological malignancy. In addition, 69% of the human squamous cell carcinomas occurred in the male sex, and 72% of the experimental carcinomas developed in males. This comparative study suggests that further studies investigating the significance of nitrosamines as suspected etiologic factors of nasal carcinogenesis in man may be useful. 3 AUTHOR Majumdar B AUTHOR Beck S TITLE Inverted papilloma of the nose. Some aspects of aetiology. SOURCE J Laryngol Otol; VOL 98, ISS 5, 1984, P467-70 ABSTRACT A study of 43 cases of inverted papilloma of the nose has been made. These cases, arising from a moderately well-defined geographical area, were seen between 1955 and 1980. A detailed clinical and histological review was made in each case. No correlation has been found between any of the variable histological features and the potential of a particular papilloma to recur. The overall incidence of transformation to carcinoma is low, even after multiple recurrences. The findings suggests that there may be an extrinsic factor contributing to the causation of these tumours. 4 AUTHOR Perzin KH AUTHOR Lefkowitch JH AUTHOR Hui RM TITLE Bilateral nasal squamous carcinoma arising in papillomatosis: report of a case developing after chemotherapy for leukemia. SOURCE Cancer; VOL 48, ISS 11, 1981, P2375-82 ABSTRACT A patient with a 25-year history of recurrent left nasal polyps is described. Recurrent papillomatosis (schneiderian or inverted papilloma) involving the left nasal cavity had been histologically documented for five years. Following the onset of and chemotherapy for acute myelomonocytic leukemia, the patient developed papillomatosis in the right nasal cavity and invasive squamous cell carcinomas in both nasal cavities. The case may represent the first reported example of apparently separate invasive carcinomas arising in nasal papillomatosis and developing in both the left and right nasal cavities.