YOU ARE NOW CONNECTED TO THE TOXLINE (1981 FORWARD, NON-ROYALTY) FILE. ==MSM - METHYLSULFONYLMETHANE== 4 AUTHOR O'Dwyer PJ AUTHOR McCabe DP AUTHOR Sickle-Santanello BJ AUTHOR Woltering EA AUTHOR Clausen K AUTHOR Martin EW Jr TITLE Use of polar solvents in chemoprevention of 1,2-dimethylhydrazine-induced colon cancer. SOURCE Cancer; VOL 62, ISS 5, 1988, P944-8 ABSTRACT To examine the effect of the polar solvents on 1,2-dimethylhydrazine (DMH)-induced colon cancer, 100 male Sprague-Dawley rats were randomly allocated to a control and three treatment groups. Treated animals received N-methylformamide (NMF), dimethylsulfoxide (DMSO), or methylsulfonylmethane (MSM) added to drinking water 1 week before carcinogen injections commenced and for the duration of the experiment. Primary tumors were detected by serial laparotomy under ether anesthesia performed at 2-month intervals and commencing after carcinogen injections had been completed. The average time to tumor onset was significantly delayed in rats receiving NMF and MSM (P = 0.0141 and 0.0398 respectively, Mantel-Haenszel test). In addition, fewer poorly differentiated tumors were noted in treatment groups. No weight loss or toxicity was observed. These findings demonstrate that the polar solvents significantly reduce the latent period to tumor onset in DMH-induced colon cancer and indicate the need to further investigate such compounds as chemopreventive agents. You are now connected to the HSDB file. 1 - HSDB NAME OF SUBSTANCE 1,2-DIMETHYLHYDRAZINE CAS REGISTRY NUMBER 540-73-8 SYNONYMS 1,2-DIMETHYL-HYDRAZINE **PEER REVIEWED** SYNONYMS 1,2-DIMETHYLHYDRAZIN (GERMAN) **PEER REVIEWED** SYNONYMS 1,2-DMH **PEER REVIEWED** SYNONYMS DMH **PEER REVIEWED** SYNONYMS HYDRAZINE, 1,2-DIMETHYL- **PEER REVIEWED** SYNONYMS N,N'-DIMETHYLHYDRAZINE **PEER REVIEWED** SYNONYMS SDMH **PEER REVIEWED** SYNONYMS SYM-DIMETHYLHYDRAZINE **PEER REVIEWED** SYNONYMS SYMETRYCZNA DWUMETYLOHYDRAZYNA (POLISH) **PEER REVIEWED** SYNONYMS SYMMETRICAL-DIMETHYLHYDRAZINE **PEER REVIEWED** SYNONYMS HYDRAZOMETHANE **PEER REVIEWED** METHODS OF MANUFACTURING PREPD FROM DIBENZOYLHYDRAZINE: FOLPMERS, REC TRAV CHIM 34, 34 (1915); HATT, ORG SYN COLL VOL II, 208 (1943). ELECTROSYNTHESIS FROM NITROMETHANE: IVERSEN, BER 104, 2195 (1971). [The Merck Index. 10th ed. Rahway, New Jersey: Merck Co., Inc., 1983., p. 473] **PEER REVIEWED** METHODS OF MANUFACTURING ... SYMMETRICAL DIALKYLHYDRAZINES SUCH AS SYMMETRICAL 1,2-DIMETHYLHYDRAZINE CAN BE MADE BY (I) REDN OF CORRESPONDING AZINE USING LITHIUM ALUMINUM HYDRIDE, (II) HYDROLYSIS OF ALKYL SUBSTITUTED DIAZACYCLOPROPANES, OR (III) REACTION OF HYDRAZINE WITH ALKYL HALIDES. [IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, V4 146 (1974)] 1972-PRESENT. (Multivolume work). V4 146 (1974)] **PEER REVIEWED** HUMAN TOXICITY EXCERPTS The Carcinogen Assessment Group (CAG), Office of Health and Environmental Assessment in EPA's Research and Development Office has prepared a list of chemical substances for which substantial or strong evidence exists showing that exposure to these chemicals, under certain conditions, causes cancer in humans, or can cause cancer in animal species which in turn, makes them potential carcinogenic in humans. Substances are placed on the CAG list only if they have been demonstrated to induce malignant tumors in one or more animal species or to induce benign tumors that are generally recognized as early stages of malignancies, and/or if positive epidemiologic studies indicated they were carcinogenic. 1,2-Dimethylhydrazine is on that list. [USEPA/CAG; The Carcinogen Assessment Group's List of Carcinogens (7/14/80)] **PEER REVIEWED** HUMAN TOXICITY EXCERPTS HIGHLY CORROSIVE & IRRITATING TO SKIN, EYES, AND MUCOUS MEMBRANES. CONVULSANT POISON. /1,1-DIMETHYLHYDRAZINE/ [The Merck Index. 10th ed. Rahway, New Jersey: Merck Co., Inc., 1983., p. 473] **PEER REVIEWED**