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                        ==CATALASE ENZYME==
 
8
AUTHOR                    Goth L
AUTHOR                    Meszaros I
AUTHOR                    Nemeth H
TITLE                     Serum catalase enzyme activity in liver
                          diseases.
SOURCE                    Acta Biol Hung; VOL 38, ISS 2, 1987, P287-90
ABSTRACT                  Serum catalase activity was moderately
                          increased in fatty liver, acute alcoholic
                          hepatitis and in the decompensated form of
                          cardiac circulatory failure. It showed
                          significant increase in acute yellow atrophy
                          and in toxic hepatitis while no changes were
                          detected in liver cirrhosis and viral
                          hepatitis. Serum catalase activity showed a
                          good correlation (r = 0.820) with the serum
                          glutamate dehydrogenase activity. In
                          accordance with our results, the inexpensive
                          assay of serum catalase activity is suggested
                          for the detection of severe liver cell
                          damage.
 
2
AUTHOR                    Harrison J
AUTHOR                    Shi X
AUTHOR                    Wang L
AUTHOR                    Ma JK
AUTHOR                    Rojanasakul Y
TITLE                     Novel delivery of antioxidant enzyme catalase
                          to alveolar macrophages by Fc
                          receptor-mediated endocytosis.
SOURCE                    Pharm Res; VOL 11, ISS 8, 1994, P1110-4
ABSTRACT                  Excessive production of reactive oxygen
                          species by alveolar macrophages (AMs) in
                          response to inhaled toxic substances is a
                          major cause of oxidative lung injury.
                          Therapeutic approaches designed to protect
                          the lungs from oxidative injury by
                          administering native antioxidant enzymes such
                          as catalase and superoxide dismutase have
                          been suggested. However, problems associated
                          with poor penetration of these enzymes to the
                          intracellular target sites have limited their
                          effective use. The present study reports a
                          drug targeting method based on
                          receptor-mediated endocytosis of the
                          antioxidant enzyme catalase to the AMs....
                          (ABSTRACT TRUNCATED AT 250 WORDS)