YOU ARE NOW CONNECTED TO THE TOXLINE (1981 FORWARD, NON-ROYALTY) FILE. ==CESIUM CHLORIDE AND ALOE== 3 AUTHOR Sartori HE TITLE Nutrients and cancer: an introduction to cesium therapy. SOURCE Pharmacol Biochem Behav; VOL 21 Suppl 1, 1984, P7-10 ABSTRACT A brief overview on the relevance in dietary factors in both development and prevention of cancer is presented. The pharmacologic properties of various food ingredients are discussed. Establishing of a special diet for the cancer patient is suggested. In addition, avoidance of certain foods is recommended to counteract mucus production of cancer cells. Evaluation of the nutrient content of certain diets in regions with low incidence of cancer has advanced the use of certain alkali metals, i.e., rubidium and cesium, as chemotherapeutic agents. The rationale for this approach termed the "high pH" therapy resides in changing the acidic pH range of the cancer cell by cesium towards weak alkalinity in which the survival of the cancer cell is endangered, and the formation of acidic and toxic materials, normally formed in cancer cells, is neutralized and eliminated. 4 AUTHOR Caldana PL AUTHOR Bentivoglio G TITLE [Use of corticotherapy for the prevention of "radiation sickness" in patients subjected to cesium therapy for gynecologic neoplasms] SOURCE Minerva Med; VOL 74, ISS 6, 1983, P235-8 ABSTRACT 193 patients treated at Genoa University's Obstetrics and Gynaecology Clinic for uterine and vaginal neoplasias by remote after-loading caesiotherapy have been studied. 100 patients were given 6-alpha-methylprednisolone hemisuccinate, a corticosteroid derivative, against "radiation disease". Only one patient had to interrupt the treatment as a result of side-effects of the drug and none of the patients showed ill effects traceable to ionising radiation, in contrast with those who only received caesiotherapy (22 out of 93 cases). Given the efficiency and special tolerance of this cortisone derivative, it would appear to be of practical use in the prophylaxis of radiation induced diseases in general. 1 AUTHOR Tufte FW AUTHOR Tufte MJ TITLE The effects of zinc gluconate, vitamin A and caesium salts on colon carcinoma in mice. SOURCE Cytobios; VOL 39, ISS 155-156, 1984, P177-82 ABSTRACT Tests have been conducted using caesium salts, zinc gluconate and vitamin A on colon carcinoma ( C38 ) implants in BDF1 mice. Preliminary work suggested a correlation between the repression of tumour growth and the use of these compounds. Present data show a high degree of tumour repression when selected amounts of these compounds are used together in a treatment protocol. 5 AUTHOR GHOSH A AUTHOR SHARMA A AUTHOR TALUKDER G TITLE Clastogenic effects of caesium chloride on human peripheral blood lymphocytes in vitro. SOURCE TOXICOL IN VITRO; 7 (2). 1993. 137-140. ABSTRACT BIOSIS COPYRIGHT: BIOL ABS. Clastogenic effects of caesium chloride (CsCl) were studied on human peripheral blood lymphocytes in vitro. The different doses of CsCl induced chromosomal aberrations in a dose-dependent manner. The aberrations were mainly of the chromatid type and the frequency was not influenced by the age or sex of the donor. 7 AUTHOR GHOSH A AUTHOR SHARMA A AUTHOR TALUKDER G TITLE Relative protection given by extract of Phyllanthus emblica fruit and an equivalent amount of vitamin C against a known clastogen, caesium chloride. SOURCE FOOD CHEM TOXICOL; 30 (10). 1992. 865-869. ABSTRACT BIOSIS COPYRIGHT: BIOL ABS. Aqueous extracts of Phyllanthus emblica L. fruit and an equivalent amount of vitamin C were administered orally by gavage to laboratory-bred Swiss albino mice for 7 days in order to evaluate the protection afforded by the two extracts against clastogenic effects of different doses of caesium chloride (CsCl) on bone marrow cells of Mus musculus in vivo. Both pretreatments significantly reduced the frequency of chromosome aberrations induced by CsCl given at three different doses, indicating that vitamin C, an essential component of P. emblica extract, was the effective agent in protecting against the clastogenicity of the metal salt. 1 AUTHOR Iena IaM TITLE [The therapeutic properties of aloe] SOURCE Vrach Delo, ISS 2-3, 1993, P142-5 (REF: 9) ABSTRACT Data are reported on the use of aloes in research and folk medicine. Aloes is used in the form of dry juice of aloe leaves, fluid extract, juice, ointments. The author discusses indications and contraindications to the use of aloe. Recipes are given of mixtures with aloe which may be used in domestic conditions for increasing the defensive forces of the body during radiation lesions. 3 AUTHOR Klein AD AUTHOR Penneys NS TITLE Aloe vera [published erratum appears in J Am Acad Dermatol 1988 Jul;19(1 Pt 1):82] SOURCE J Am Acad Dermatol; VOL 18, ISS 4 Pt 1, 1988, P714-20 (REF: 27) ABSTRACT We review the scientific literature regarding the aloe vera plant and its products. Aloe vera is known to contain several pharmacologically active ingredients, including a carboxypeptidase that inactivates bradykinin in vitro, salicylates, and a substance(s) that inhibits thromboxane formation in vivo. Scientific studies exist that support an antibacterial and antifungal effect for substance(s) in aloe vera. Studies and case reports provide support for the use of aloe vera in the treatment of radiation ulcers and stasis ulcers in man and burn and frostbite injuries in animals. The evidence for a potential beneficial effect associated with the use of aloe vera is sufficient to warrant the design and implementation of well-controlled clinical trials. 4 AUTHOR Grindlay D AUTHOR Reynolds T TITLE The Aloe vera phenomenon: a review of the properties and modern uses of the leaf parenchyma gel. SOURCE J Ethnopharmacol; VOL 16, ISS 2-3, 1986, P117-51 (REF: 154) ABSTRACT The mucilaginous gel from the parenchymatous cells in the leaf pulp of Aloe vera has been used since early times for a host of curative purposes. This gel should be distinguished clearly from the bitter yellow exudate originating from the bundle sheath cells, which is used for its purgative effects. Aloe vera gel has come to play a prominent role as a contemporary folk remedy, and numerous optimistic, and in some cases extravagant, claims have been made for its medicinal properties. Modern clinical use of the gel began in the 1930s, with reports of successful treatment of X-ray and radium burns, which led to further experimental studies using laboratory animals in the following decades. The reports of these experiments and the numerous favourable case histories did not give conclusive evidence, since although positive results were usually described, much of the work suffered from poor experimental design and insufficiently large test samples. In addition some conflicting or inconsistent results were obtained. With the recent resurgence of interest in Aloe vera gel, however, new experimental work has indicated the possibility of distinct physiological effects. Chemical analysis has shown the gel to contain various carbohydrate polymers, notably either glucomannans or pectic acid, along with a range of other organic and inorganic components. Although many physiological properties of the gel have been described, there is no certain correlation between these and the identified gel components.