YOU ARE NOW CONNECTED TO THE TOXLINE (1981 FORWARD, NON-ROYALTY) FILE. ==ADENOMA, HEPATIC AND CONTRACEPTIVES== 3 AUTHOR Buhler H AUTHOR Pirovino M AUTHOR Akobiantz A AUTHOR Altorfer J AUTHOR Weitzel M AUTHOR Maranta E AUTHOR Schmid M TITLE Regression of liver cell adenoma. A follow-up study of three consecutive patients after discontinuation of oral contraceptive use. SOURCE Gastroenterology; VOL 82, ISS 4, 1982, P775-82 ABSTRACT Three consecutive young female patients with unresected liver cell adenoma and a history of contraceptive use of several years' duration were followed up over a period of 2-4.5 yr after withdrawal of hormonal medication. One patient presented multiple adenomas and in another, the adenoma was associated with a Budd-Chiari syndrome due to bilateral thrombotic hepatic vein occlusion. Complete regression of the adenomas was documented in all 3 patients by ultrasonography, liver radionuclide scan, laparoscopy, or computerized tomography. It is concluded that, in selected cases, conservative management after withdrawal of hormonal contraception may be a valid alternative to surgical therapy. 8 AUTHOR Gyorffy EJ AUTHOR Bredfeldt JE AUTHOR Black WC TITLE Transformation of hepatic cell adenoma to hepatocellular carcinoma due to oral contraceptive use SOURCE Ann. Intern. Med.; VOL 110 ISS Mar 15 1989, P489-490, (REF 10) ABSTRACT IPA COPYRIGHT: ASHP Transformation of a hepatic cell adenoma to a hepatocellular carcinoma attributed to use of Ovral, a combination of ethinyl estradiol and norgestrel, for 22 yr, is reported in a 53-yr-old patient. The contraceptive was withdrawn and the lesion monitored without specific therapy. 9 AUTHOR Gordon SC AUTHOR Reddy KR AUTHOR Livingstone AS AUTHOR Jeffers LJ AUTHOR Schiff ER TITLE Resolution of a contraceptive-steroid-induced hepatic adenoma with subsequent evolution into hepatocellular carcinoma SOURCE Ann. Intern. Med.; VOL 105 ISS Oct 1986, P547-549, (REF 10) ABSTRACT IPA COPYRIGHT: ASHP The case of a 36-yr-old woman who had been taking contraceptive steroids for 14 yr and norethindrone and mestranol combination for the last 7, who developed hepatic adenoma which resolved after withdrawal of the drug but later evolved to hepatocellular carcinoma is reported; the patient was treated successfully with surgery. The need to follow patients who develop contraceptive steroid-related adenomas by ultrasonography for many years is discussed. 11 AUTHOR Scott LD AUTHOR Katz AR AUTHOR Duke JH AUTHOR Cowan DF AUTHOR Maklad NF TITLE Oral contraceptives, pregnancy, and focal nodular hyperplasia of the liver. SOURCE JAMA; VOL 251, ISS 11, 1984, P1461-3 ABSTRACT There is uncertainty regarding the role, if any, of oral contraceptive steroids in the development of focal nodular hyperplasia of the liver. In a 36-year-old woman, a large left hepatic lobe tumor developed that was detected after 11 years of using these drugs. The tumor regressed when administration of the drug was stopped but began to increase in size during a subsequent pregnancy. A left hepatic lobectomy during the second trimester disclosed focal nodular hyperplasia. Both contraceptive steroids and pregnancy, with high levels of endogenous sex steroids, favored tumor growth in this patient, suggesting that focal nodular hyperplasia can be steroid related.